MACIR

Across TCGA patient cohorts, MACIR mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MACIR-associated genes across cancer lineages are MEK1, 4E-BP1, and eEF2. Each is linked with MACIR in more than 1 cancer types. Because this analysis shows association rather than direction, both MACIR-to-partner and partner-to-MACIR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by MACIR-low versus MACIR-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MACIR→partner) and Y-score (partner→MACIR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.408	+2.321	.016	.034	3	2
UCEC	4E-BP1 →	+0.513	+3.351	<.001	.005	3	2
UCEC	eEF2 →	+0.501	+3.000	.002	.036	2	2
UCEC	A-Raf_pS299 →	-0.124	-3.169	.026	.019	3	1
UCEC	JNK2 →	+0.342	+3.026	<.001	.018	3	1
UCEC	Ku80 →	+0.226	+1.887	.039	.031	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

MEK1 by MACIR expression — UCEC

Explore this box plot interactively →