MAB21L2

Across TCGA patient cohorts, MAB21L2 mutation is significantly associated with the RNA expression of many other genes, with 1,813 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAB21L2-associated genes across cancer lineages are KLHL36, MIR8053, and MIR4667. Each is linked with MAB21L2 in more than 2 cancer types. Because this analysis shows association rather than direction, both MAB21L2-to-partner and partner-to-MAB21L2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KLHL36 grouped by MAB21L2-low versus MAB21L2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAB21L2→partner) and Y-score (partner→MAB21L2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	KLHL36 →	+0.495	+3.103	<.001	<.001	3	3
STAD	MIR8053 →	+0.247	+3.330	.003	.008	3	3
BRCA	MIR4667 →	+0.313	+5.288	<.001	.006	3	2
BRCA	RN7SKP221 →	+0.065	+7.471	<.001	.008	3	2
UCEC	HIRA →	+0.368	+1.737	.002	.002	3	2
UCEC	VGLL1 →	-0.902	-2.000	.007	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,813 associations by consensus.

KLHL36 by MAB21L2 expression — UCEC

Explore this box plot interactively →