MAB21L2

Across TCGA pan-cancer cohorts, MAB21L2 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated MAB21L2 data layer compared with 7 for mutation status.

The strongest signal is observed in brain lower grade glioma (LGG), where higher MAB21L2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated MAB21L2 expression acts as an unfavorable survival marker, although some lineages such as THCA and SCLC show a favorable association.

LGG, ACC, and LUSC are the cancer types where MAB21L2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	OS	Median	All	0.339	0.537	<.001	54	view →
ACC	DFS	Quartile	All	0.326	0.736	.005	53	view →
LUSC	OS	Tertile	IV	0.057	0.786	.008	36	view →
THCA	DFS	Quartile	All	0.890	0.700	.003	24	view →
OV	DFS	Tertile	All	0.479	0.580	.009	24	view →
SCLC	OS	Tertile	III,IV	0.837	0.469	.002	19	view →
COAD	DFS	Median	All	0.630	0.739	.012	14	view →
LUAD	OS	Quartile	All	0.809	0.583	.002	13	view →
ESCA	OS	Tertile	IV	0.135	0.713	.038	12	view →
CHOL	DFS	Quartile	II,III,IV	0.180	0.577	.024	12	view →
SARC	DFS	Tertile	All	0.481	0.666	.003	8	view →
SKCM	OS	Tertile	All	0.952	0.836	.018	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

MAB21L2–LGG (OS)

Open the LGG breakdown →