M1AP

Across TCGA patient cohorts, M1AP mutation is significantly associated with the RNA expression of many other genes, with 3,114 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible M1AP-associated genes across cancer lineages are OR6C68, RNU2-27P, and RNU6-720P. Each is linked with M1AP in more than 2 cancer types. Because this analysis shows association rather than direction, both M1AP-to-partner and partner-to-M1AP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR6C68 grouped by M1AP-low versus M1AP-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (M1AP→partner) and Y-score (partner→M1AP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	OR6C68 →	+0.031	+4.814	<.001	.003	3	3
SKCM	RNU2-27P →	+0.676	+2.057	.002	.005	3	2
SKCM	RNU6-720P →	+0.334	+2.326	.009	.001	3	2
UCEC	MRPL46 →	+0.406	+2.660	<.001	<.001	3	2
SKCM	CENPN-AS1 →	+0.223	+3.347	.001	.004	3	2
SKCM	MIR5089 →	+0.275	+1.903	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,114 associations by consensus.

OR6C68 by M1AP expression — BLCA

Explore this box plot interactively →