M1AP

Across TCGA pan-cancer cohorts, M1AP RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated M1AP data layer compared with 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher M1AP RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated M1AP expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and KIRP are the cancer types where M1AP RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	II,III,IV	0.399	0.236	<.001	143	view →
SKCM	OS	Quartile	All	0.884	0.618	<.001	67	view →
KIRP	DFS	Tertile	All	0.965	0.840	.002	54	view →
LUSC	OS	Median	III,IV	0.514	0.174	<.001	37	view →
STAD	DFS	Tertile	IV	0.100	0.538	.006	33	view →
CHOL	OS	Median	All	1.000	0.326	<.001	32	view →
LUAD	OS	Tertile	All	0.765	0.608	.002	30	view →
KIRC	DFS	Quartile	IV	0.384	0.699	.010	28	view →
ACC	DFS	Tertile	All	0.738	0.404	.007	26	view →
LAML	DFS	Median	All	0.499	0.262	.001	26	view →
LGG	DFS	Quartile	All	0.590	0.789	<.001	26	view →
CESC	OS	Quartile	All	0.732	0.510	.020	20	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

M1AP–HNSC (DFS)

Open the HNSC breakdown →