M1AP

Across TCGA pan-cancer cohorts, M1AP RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of M1AP’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where M1AP RNA is repressed in tumor relative to normal tissue. In most cancer types M1AP is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, KICH, and STAD are the cancer types where M1AP tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in M1AP RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−1.097	<.001	11	view →
KICH	Male	All	−1.813	<.001	10	view →
STAD	All	II,III,IV	+1.162	<.001	8	view →
LUAD	Male	All	−0.807	<.001	7	view →
KIRP	All	All	−0.596	.002	6	view →
LUSC	Male	II,III,IV	−0.771	<.001	5	view →
HNSC	Male	II,III,IV	+0.677	.033	5	view →
ESCA	All	II,III,IV	+2.545	.004	4	view →
CHOL	All	All	+0.702	.028	3	view →
THCA	All	All	+0.315	.023	3	view →
UCEC	All	All	+1.426	<.001	2	view →
BRCA	All	IV	−0.665	.024	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

M1AP–KIRC

Open the KIRC breakdown →