M1AP

Across TCGA patient cohorts, M1AP mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible M1AP-associated genes across cancer lineages are ATM, Caspase-7-cleavedD198, and INPP4B. Each is linked with M1AP in more than 2 cancer types. Because this analysis shows association rather than direction, both M1AP-to-partner and partner-to-M1AP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by M1AP-low versus M1AP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (M1AP→partner) and Y-score (partner→M1AP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.716	-2.584	<.001	.010	3	2
UCEC	Caspase-7-cleavedD198 →	+0.843	+3.459	<.001	.005	3	2
SKCM	INPP4B →	-0.178	-3.309	.039	.009	3	1
SKCM	NDRG1_pT346 →	-0.600	-3.000	.042	.034	3	1
SKCM	TAZ →	+0.179	+2.700	.011	.006	3	1
SKCM	ASNS →	+0.483	+3.169	.012	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

ATM by M1AP expression — UCEC

Explore this box plot interactively →