M1AP

Across TCGA cell cohorts, M1AP mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible M1AP-associated genes across cancer lineages are OR2K2, IFNA8, and ACSM4. Each is linked with M1AP in more than 1 cancer types. Because this analysis shows association rather than direction, both M1AP-to-partner and partner-to-M1AP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2K2 grouped by M1AP-low versus M1AP-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (M1AP→partner) and Y-score (partner→M1AP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR2K2 →	+0.042	+3.882	<.001	.003	3	2
BLOOD_Leukemia	IFNA8 →	+0.024	+4.539	.001	<.001	3	1
BLOOD_Leukemia	ACSM4 →	+0.032	+3.234	.003	.008	3	1
LUNG_NSCLC_LUAD	TBATA →	+0.153	+3.959	<.001	.001	3	1
LUNG_NSCLC_LUAD	PADI6 →	+0.044	+4.188	<.001	.001	3	1
LUNG_NSCLC_LUAD	AMELY →	+0.047	+3.604	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

OR2K2 by M1AP expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →