LZTS2

Across TCGA patient cohorts, LZTS2 mutation is significantly associated with the RNA expression of many other genes, with 3,332 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LZTS2-associated genes across cancer lineages are MIR425, RNU6-492P, and RN7SKP21. Each is linked with LZTS2 in more than 2 cancer types. Because this analysis shows association rather than direction, both LZTS2-to-partner and partner-to-LZTS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR425 grouped by LZTS2-low versus LZTS2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LZTS2→partner) and Y-score (partner→LZTS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR425 →	+0.254	+1.827	.009	.004	3	3
HNSC	RNU6-492P →	+0.478	+7.954	<.001	.008	3	2
SKCM	RN7SKP21 →	+0.152	+4.797	<.001	.003	3	2
UCEC	MYO19 →	+0.470	+2.392	<.001	<.001	3	2
UCEC	RNA5SP411 →	+0.922	+2.045	<.001	<.001	3	2
UCEC	SENP3-EIF4A1 →	+0.105	+2.456	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,332 associations by consensus.

MIR425 by LZTS2 expression — UCEC

Explore this box plot interactively →