LZTS2

Across TCGA pan-cancer cohorts, LZTS2 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of LZTS2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where LZTS2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LZTS2 is over-expressed in tumor, although a few such as BLCA and KICH show the opposite, repressed pattern.

KIRP, THCA, and LIHC are the cancer types where LZTS2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LZTS2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	Male	III,IV	+0.932	<.001	11	view →
THCA	Male	III,IV	+0.834	<.001	10	view →
LIHC	Female	II,III,IV	+1.871	<.001	9	view →
HNSC	All	All	+0.419	.003	6	view →
KIRC	All	All	+0.288	.001	6	view →
CHOL	Male	All	+3.143	<.001	5	view →
BLCA	Male	III,IV	−1.004	.012	4	view →
KICH	All	All	−0.764	<.001	4	view →
COAD	Female	All	+0.665	<.001	4	view →
LUSC	All	All	+0.316	.002	4	view →
BRCA	Female	All	−0.195	.012	4	view →
PRAD	All	All	−0.347	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

LZTS2–KIRP

Open the KIRP breakdown →