LYZL2

Across TCGA patient cohorts, LYZL2 mutation is significantly associated with the RNA expression of many other genes, with 486 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LYZL2-associated genes across cancer lineages are SSXP4, RN7SL354P, and SNRPEP7. Each is linked with LYZL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both LYZL2-to-partner and partner-to-LYZL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SSXP4 grouped by LYZL2-low versus LYZL2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LYZL2→partner) and Y-score (partner→LYZL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SSXP4 →	+0.050	+4.148	.007	.006	3	2
UCEC	RN7SL354P →	+0.293	+2.374	<.001	.006	3	2
LUAD	SNRPEP7 →	+0.183	+3.962	<.001	.005	3	2
HNSC	RNU6-1313P →	+0.323	+5.111	<.001	.004	3	1
HNSC	KIRREL3-AS3 →	+0.150	+4.221	<.001	.009	3	1
UCEC	SNX3P1Y →	+0.149	+5.156	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 486 associations by consensus.

SSXP4 by LYZL2 expression — UCEC

Explore this box plot interactively →