LYN

Across TCGA patient cohorts, LYN RNA expression is significantly associated with the RNA expression of many other genes, with 19,081 significant associations in total. UVM shows the largest number of these associations.

The most reproducible LYN-associated genes across cancer lineages are TLR8, SH2B3, and TLR4. Each is linked with LYN in more than 32 cancer types. Because this analysis shows association rather than direction, both LYN-to-partner and partner-to-LYN results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, LYN versus TLR8 in LAML, with a Pearson correlation of 0.71.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LYN→partner) and Y-score (partner→LYN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LAML	TLR8 →	+2.823	+0.922	<.001	<.001	3	33
DLBC	SH2B3 →	+1.515	+1.291	<.001	<.001	3	33
LAML	TLR4 →	+1.734	+0.729	<.001	<.001	3	33
SKCM	GPR65 →	+1.505	+1.678	<.001	<.001	3	33
DLBC	PARP14 →	+1.467	+1.099	<.001	<.001	3	33
LAML	MPEG1 →	+2.916	+0.771	<.001	<.001	3	33

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,081 associations by consensus.

LYN vs TLR8 — LAML

Explore this scatter interactively →