LYN

Across TCGA pan-cancer cohorts, LYN RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated LYN data layer compared with 5 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher LYN RNA is associated with worse overall survival. In most high-consensus cancer types, elevated LYN expression acts as an unfavorable survival marker, although some lineages such as SKCM and KIRC show a favorable association.

UVM, KIRP, and LGG are the cancer types where LYN RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.415	0.778	<.001	117	view →
KIRP	DFS	Median	II,III,IV	0.507	0.820	.001	109	view →
LGG	OS	Median	All	0.742	0.882	<.001	48	view →
SKCM	OS	Tertile	All	0.447	0.278	.001	43	view →
LAML	DFS	Median	All	0.244	0.511	.002	36	view →
KIRC	DFS	Quartile	All	0.882	0.708	.005	32	view →
THYM	DFS	Quartile	All	0.764	1.000	.002	26	view →
BLCA	DFS	Median	All	0.500	0.683	.013	20	view →
HNSC	OS	Quartile	All	0.402	0.733	.001	19	view →
ESCA	OS	Median	All	0.418	1.000	.005	18	view →
CESC	DFS	Quartile	All	0.893	0.758	.016	18	view →
LUSC	DFS	Tertile	III,IV	0.734	0.463	.018	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

LYN–UVM (OS)

Open the UVM breakdown →