LY6D

Across TCGA patient cohorts, LY6D mutation is significantly associated with the RNA expression of many other genes, with 59 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LY6D-associated genes across cancer lineages are RNU6-660P, RNU6-376P, and MTATP6P21. Each is linked with LY6D in more than 1 cancer types. Because this analysis shows association rather than direction, both LY6D-to-partner and partner-to-LY6D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-660P grouped by LY6D-low versus LY6D-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LY6D→partner) and Y-score (partner→LY6D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-660P →	+0.632	+3.889	<.001	.004	3	2
UCEC	RNU6-376P →	+0.589	+4.453	<.001	.006	3	2
UCEC	MTATP6P21 →	+1.059	+5.289	<.001	<.001	3	2
BRCA	RNA5SP100 →	+0.277	+8.055	<.001	.007	3	2
UCEC	HMGB1P50 →	+0.360	+3.413	<.001	.006	3	1
UCEC	RPS29P32 →	+1.026	+3.599	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 59 associations by consensus.

RNU6-660P by LY6D expression — UCEC

Explore this box plot interactively →