LVRN

Across TCGA patient cohorts, LVRN mutation is significantly associated with the RNA expression of many other genes, with 5,258 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LVRN-associated genes across cancer lineages are PHF5A, GPRIN1, and RCC1. Each is linked with LVRN in more than 3 cancer types. Because this analysis shows association rather than direction, both LVRN-to-partner and partner-to-LVRN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PHF5A grouped by LVRN-low versus LVRN-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LVRN→partner) and Y-score (partner→LVRN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	PHF5A →	+0.401	+2.099	.001	.003	3	4
LUAD	GPRIN1 →	+1.059	+3.247	<.001	<.001	3	4
LUAD	RCC1 →	+0.505	+2.906	.001	.001	3	4
LUAD	NR2C2AP →	+0.437	+3.816	<.001	<.001	3	4
UCEC	ITGA7 →	-0.457	-1.716	.003	.003	3	4
UCEC	TXN →	+0.347	+1.820	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,258 associations by consensus.

PHF5A by LVRN expression — LUAD

Explore this box plot interactively →