LVRN

Across TCGA pan-cancer cohorts, LVRN RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated LVRN data layer compared with 7 for mutation status.

The strongest signal is observed in uveal melanoma (UVM), where higher LVRN RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated LVRN expression acts as an unfavorable survival marker, although some lineages such as COAD and UCS show a favorable association.

UVM, CESC, and STAD are the cancer types where LVRN RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Tertile	II,III,IV	0.293	0.704	.001	96	view →
CESC	DFS	Tertile	II,III,IV	0.301	0.723	.001	90	view →
STAD	DFS	Quartile	All	0.276	0.636	<.001	63	view →
KICH	OS	Quartile	II,III,IV	0.533	1.000	.002	62	view →
OV	OS	Median	III,IV	0.619	0.736	.002	50	view →
LIHC	OS	Quartile	All	0.678	0.861	<.001	39	view →
LUAD	DFS	Quartile	III,IV	0.176	0.514	.006	37	view →
PAAD	OS	Median	All	0.299	0.459	.007	27	view →
READ	DFS	Median	All	0.413	0.670	.004	20	view →
COAD	DFS	Quartile	IV	0.654	0.170	<.001	18	view →
KIRC	DFS	Tertile	II,III,IV	0.419	0.589	.011	17	view →
UCS	DFS	Tertile	IV	0.860	0.364	.024	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

LVRN–UVM (DFS)

Open the UVM breakdown →