LTK

Across TCGA patient cohorts, LTK mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LTK-associated genes across cancer lineages are 14-3-3_beta, Notch1, and p27_pT157. Each is linked with LTK in more than 1 cancer types. Because this analysis shows association rather than direction, both LTK-to-partner and partner-to-LTK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by LTK-low versus LTK-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LTK→partner) and Y-score (partner→LTK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.103	-1.973	.006	.029	3	2
UCEC	Notch1 →	+0.210	+2.662	<.001	<.001	3	2
UCEC	p27_pT157 →	-0.062	-1.861	.004	.049	3	2
UCEC	BRCA2 →	-0.114	-2.211	.019	.010	3	2
UCEC	EGFR →	-0.210	-2.433	<.001	.018	3	1
UCEC	FoxM1 →	+0.198	+1.765	.041	.014	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

14-3-3_beta by LTK expression — UCEC

Explore this box plot interactively →