LTK

Across TCGA pan-cancer cohorts, LTK RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of LTK’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where LTK RNA is repressed in tumor relative to normal tissue. In most cancer types LTK is over-expressed in tumor, although a few such as KIRC and COAD show the opposite, repressed pattern.

KIRC, COAD, and LUSC are the cancer types where LTK tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LTK RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	IV	−1.050	<.001	12	view →
COAD	All	III,IV	−1.800	<.001	9	view →
LUSC	Female	All	−1.661	<.001	9	view →
KIRP	Male	II,III,IV	−1.369	<.001	9	view →
LIHC	Male	II,III,IV	−1.002	<.001	7	view →
UCEC	All	All	+0.826	.006	6	view →
BRCA	All	All	−0.240	<.001	6	view →
BLCA	Male	All	+1.297	.017	4	view →
READ	All	All	−1.802	.007	3	view →
PRAD	All	All	−0.106	.022	2	view →
KICH	Male	IV	−1.106	.007	1	view →
STAD	Male	All	+0.935	.036	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

LTK–KIRC

Open the KIRC breakdown →