LTK

Across TCGA cell cohorts, LTK mutation is significantly associated with the RNA expression of many other genes, with 21 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible LTK-associated genes across cancer lineages are GZMH, DCD, and CLRN1. Each is linked with LTK in more than 1 cancer types. Because this analysis shows association rather than direction, both LTK-to-partner and partner-to-LTK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GZMH grouped by LTK-low versus LTK-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LTK→partner) and Y-score (partner→LTK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	GZMH →	+0.049	+5.285	<.001	.003	3	1
BLOOD_Lymphoma	DCD →	+0.043	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	CLRN1 →	+0.012	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	SPAG11A →	+0.066	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	OTOL1 →	+0.019	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	MRGPRE →	+0.019	+5.209	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

GZMH by LTK expression — STOMACH

Explore this box plot interactively →