LTF

Across TCGA patient cohorts, LTF mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LTF-associated genes across cancer lineages are eIF4E, A-Raf_pS299, and JNK2. Each is linked with LTF in more than 3 cancer types. Because this analysis shows association rather than direction, both LTF-to-partner and partner-to-LTF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by LTF-low versus LTF-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LTF→partner) and Y-score (partner→LTF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	eIF4E →	+0.268	+2.832	.006	.035	3	4
UCEC	A-Raf_pS299 →	-0.115	-1.847	.001	.007	3	2
UCEC	JNK2 →	+0.203	+1.775	<.001	.007	3	2
UCEC	4E-BP1 →	+0.300	+3.906	<.001	<.001	3	2
UCEC	Cyclin-B1 →	+0.778	+1.893	<.001	<.001	3	2
UCEC	Di-Ras3 →	-0.102	-2.102	.026	.016	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

eIF4E by LTF expression — COAD

Explore this box plot interactively →