LTF

Across TCGA cell cohorts, LTF mutation is significantly associated with the RNA expression of many other genes, with 22 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible LTF-associated genes across cancer lineages are PROP1, REG1B, and OR52E2. Each is linked with LTF in more than 1 cancer types. Because this analysis shows association rather than direction, both LTF-to-partner and partner-to-LTF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PROP1 grouped by LTF-low versus LTF-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LTF→partner) and Y-score (partner→LTF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PROP1 →	+0.021	+3.704	<.001	.001	3	2
LARGE_INTESTINE	REG1B →	+1.915	+2.518	<.001	.006	3	2
BREAST	OR52E2 →	+0.023	+5.169	<.001	.005	3	1
BLOOD_Leukemia	RIMS4 →	+0.299	+3.675	<.001	.003	3	1
BLOOD_Leukemia	ATP4A →	+0.215	+3.754	<.001	.008	3	1
BLOOD_Leukemia	SLC17A2 →	+0.009	+3.269	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

PROP1 by LTF expression — BLOOD_Leukemia

Explore this box plot interactively →