LTA4H

Across TCGA patient cohorts, LTA4H mutation is significantly associated with the RNA expression of many other genes, with 2,189 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LTA4H-associated genes across cancer lineages are RNU6-391P, CRYBB2P1, and NDUFAF5. Each is linked with LTA4H in more than 3 cancer types. Because this analysis shows association rather than direction, both LTA4H-to-partner and partner-to-LTA4H results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-391P grouped by LTA4H-low versus LTA4H-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LTA4H→partner) and Y-score (partner→LTA4H) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RNU6-391P →	+0.589	+7.930	<.001	.008	3	4
UCEC	CRYBB2P1 →	+0.679	+2.523	<.001	.001	3	2
UCEC	NDUFAF5 →	+0.376	+2.075	.001	.005	3	2
UCEC	CCDC9 →	+0.343	+2.010	.009	.006	3	2
UCEC	RPA3 →	+0.571	+2.513	<.001	.001	3	2
UCEC	MICU1 →	+0.399	+2.064	.002	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,189 associations by consensus.

RNU6-391P by LTA4H expression — LUAD

Explore this box plot interactively →