LTA4H

Across TCGA pan-cancer cohorts, LTA4H RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated LTA4H data layer compared with 7 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher LTA4H RNA is associated with better overall survival. In most high-consensus cancer types, elevated LTA4H expression acts as an unfavorable survival marker, although some lineages such as UVM and BRCA show a favorable association.

UVM, BRCA, and KIRC are the cancer types where LTA4H RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.806	0.422	<.001	130	view →
BRCA	OS	Median	All	0.979	0.945	<.001	116	view →
KIRC	DFS	Median	All	0.718	0.546	<.001	91	view →
UCS	OS	Tertile	III,IV	0.636	0.198	.013	44	view →
ACC	DFS	Median	All	0.409	0.753	<.001	42	view →
HNSC	OS	Median	II,III,IV	0.259	0.441	<.001	38	view →
LIHC	DFS	Quartile	All	0.273	0.566	.003	32	view →
OV	OS	Quartile	All	0.309	0.419	.016	28	view →
SKCM	DFS	Median	All	0.665	0.571	.007	25	view →
MESO	DFS	Median	IV	0.189	0.521	.002	24	view →
BLCA	OS	Tertile	IV	0.356	0.721	.018	24	view →
READ	OS	Median	IV	1.000	0.702	.008	19	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

LTA4H–UVM (OS)

Open the UVM breakdown →