LTA4H

Across TCGA cell cohorts, LTA4H mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LTA4H-associated genes across cancer lineages are AVP, CFHR2, and LILRA1. Each is linked with LTA4H in more than 1 cancer types. Because this analysis shows association rather than direction, both LTA4H-to-partner and partner-to-LTA4H results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AVP grouped by LTA4H-low versus LTA4H-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LTA4H→partner) and Y-score (partner→LTA4H) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	AVP →	+0.045	+3.632	<.001	.003	3	2
LARGE_INTESTINE	CFHR2 →	+0.038	+4.022	<.001	.006	3	2
LARGE_INTESTINE	LILRA1 →	+0.009	+3.510	.003	.003	3	1
LUNG_SCLC	POTEB →	+0.010	+4.643	<.001	.004	3	1
LUNG_SCLC	SCYGR10 →	+0.267	+4.817	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

AVP by LTA4H expression — LARGE_INTESTINE

Explore this box plot interactively →