LSS

Across TCGA patient cohorts, LSS mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LSS-associated genes across cancer lineages are mTOR_pS2448, A-Raf_pS299, and FoxM1. Each is linked with LSS in more than 2 cancer types. Because this analysis shows association rather than direction, both LSS-to-partner and partner-to-LSS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by LSS-low versus LSS-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LSS→partner) and Y-score (partner→LSS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.156	-1.874	.001	.002	3	3
UCEC	A-Raf_pS299 →	-0.135	-2.700	<.001	.005	3	2
UCEC	FoxM1 →	+0.204	+1.710	.018	.025	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.335	-2.087	.026	.005	3	2
UCEC	Rad50 →	-0.221	-2.571	.006	.010	3	2
UCEC	Rictor_pT1135 →	-0.102	-3.807	.002	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

mTOR_pS2448 by LSS expression — UCEC

Explore this box plot interactively →