LSS

Across TCGA pan-cancer cohorts, LSS RNA is linked to patient survival in 30 of 34 cancer types, making it the most broadly survival-associated LSS data layer compared with 6 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher LSS RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated LSS expression acts as an unfavorable survival marker, although some lineages such as PAAD and UCS show a favorable association.

CESC, BLCA, and BRCA are the cancer types where LSS RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	DFS	Quartile	All	0.428	0.711	<.001	100	view →
BLCA	OS	Median	All	0.309	0.536	<.001	81	view →
BRCA	OS	Median	II,III,IV	0.494	0.622	.001	55	view →
KICH	OS	Median	III,IV	0.766	1.000	.006	50	view →
ACC	DFS	Median	All	0.189	0.671	<.001	49	view →
OV	OS	Tertile	III,IV	0.294	0.399	.008	38	view →
STAD	OS	Median	II,III,IV	0.489	0.647	.006	34	view →
PAAD	DFS	Quartile	II,III,IV	0.515	0.307	.005	33	view →
UCS	DFS	Quartile	II,III,IV	0.732	0.153	.008	22	view →
LUAD	OS	Tertile	III,IV	0.634	0.309	.004	22	view →
ESCA	OS	Median	IV	0.698	0.222	.006	21	view →
READ	OS	Quartile	All	0.802	0.514	.019	19	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 30 lineages.

LSS–CESC (DFS)

Open the CESC breakdown →