LSS

Across TCGA pan-cancer cohorts, LSS RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of LSS’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where LSS RNA is repressed in tumor relative to normal tissue. In most cancer types LSS is over-expressed in tumor, although a few such as THCA and LUAD show the opposite, repressed pattern.

THCA, LUAD, and COAD are the cancer types where LSS tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LSS RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−0.734	<.001	9	view →
LUAD	Male	II,III,IV	−1.133	<.001	8	view →
COAD	All	II,III,IV	+0.432	.004	8	view →
KIRC	Male	II,III,IV	−0.644	<.001	7	view →
LIHC	Male	All	+1.081	<.001	6	view →
HNSC	All	All	+0.414	<.001	6	view →
LUSC	Male	All	−0.514	<.001	4	view →
BRCA	All	II,III,IV	−0.330	<.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

LSS–THCA

Open the THCA breakdown →