LSS

Across TCGA cell cohorts, LSS RNA expression is significantly associated with the go_rna of many other GO terms, with 3,899 significant associations in total. CNS shows the largest number of these associations.

The most reproducible LSS-associated GO terms across cancer lineages are Terpenoid biosynthetic process, Farnesyl diphosphate biosynthetic process, mevalonate pathway, and Isoprenoid biosynthetic process via mevalonate. Each is linked with LSS in more than 19 cancer types. Because this analysis shows association rather than direction, both LSS-to-partner and partner-to-LSS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Terpenoid biosynthetic process grouped by LSS-low versus LSS-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (LSS→partner) and Y-score (partner→LSS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Terpenoid biosynthetic process →	+0.229	+1.745	.002	.001	3	20
URINARY_TRACT	Farnesyl diphosphate biosynthetic process, mevalonate pathway →	+0.228	+1.232	<.001	.007	2	20
URINARY_TRACT	Isoprenoid biosynthetic process via mevalonate →	+0.228	+1.232	<.001	.007	2	20
OESOPHAGUS	Cholesterol biosynthetic process via desmosterol →	+0.269	+1.888	<.001	<.001	3	19
URINARY_TRACT	Zymosterol metabolic process →	+0.275	+1.545	<.001	<.001	3	19
URINARY_TRACT	Zymosterol biosynthetic process →	+0.275	+1.545	<.001	<.001	3	19

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,899 associations by consensus.

Terpenoid biosynthetic process by LSS expression — STOMACH

Explore this box plot interactively →