LSS

Across TCGA cell cohorts, LSS mutation is significantly associated with the RNA expression of many other genes, with 31 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible LSS-associated genes across cancer lineages are CDH20, SRSF12, and MS4A14. Each is linked with LSS in more than 1 cancer types. Because this analysis shows association rather than direction, both LSS-to-partner and partner-to-LSS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CDH20 grouped by LSS-low versus LSS-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LSS→partner) and Y-score (partner→LSS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CDH20 →	+0.125	+3.222	<.001	.002	3	1
LARGE_INTESTINE	SRSF12 →	+0.318	+3.392	.008	.006	3	1
LARGE_INTESTINE	MS4A14 →	+0.013	+2.791	<.001	.005	3	1
LARGE_INTESTINE	TAFA1 →	+0.205	+2.688	.004	.008	3	1
LARGE_INTESTINE	CENPVL3 →	+0.204	+2.657	<.001	.007	3	1
LARGE_INTESTINE	ELOA3P →	+0.093	+3.082	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

CDH20 by LSS expression — LARGE_INTESTINE

Explore this box plot interactively →