LSS

Across TCGA cell cohorts, LSS mutation is significantly associated with the mutation status of many other genes, with 3,826 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LSS-associated genes across cancer lineages are LENG8, PIGO, and TBK1. Each is linked with LSS in more than 3 cancer types. Because this analysis shows association rather than direction, both LSS-to-partner and partner-to-LSS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LENG8 grouped by LSS-low versus LSS-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LSS→partner) and Y-score (partner→LSS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	LENG8 →	+5.415	+5.415	.004	.004	1	4
OVARY	PIGO →	+4.415	+4.977	.007	.007	1	4
LUNG_SCLC	TBK1 →	+5.502	+5.502	.003	.003	1	4
BLOOD_Lymphoma	RBM12B →	+4.014	+4.969	.008	.008	1	4
BLOOD_Leukemia	TTC37 →	+3.498	+3.063	.006	.006	1	4
OVARY	WASF3 →	+4.415	+4.977	.007	.007	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,826 associations by consensus.

LENG8 by LSS expression — OVARY

Explore this box plot interactively →