LSM8

Across TCGA patient cohorts, LSM8 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. LIHC shows the largest number of these associations.

The most reproducible LSM8-associated genes across cancer lineages are RNA5SP386, RNU6-452P, and LINC01867. Each is linked with LSM8 in more than 1 cancer types. Because this analysis shows association rather than direction, both LSM8-to-partner and partner-to-LSM8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP386 grouped by LSM8-low versus LSM8-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LSM8→partner) and Y-score (partner→LSM8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	RNA5SP386 →	+0.441	+6.008	<.001	.002	3	1
LIHC	RNU6-452P →	+0.590	+6.008	<.001	.002	3	1
LIHC	LINC01867 →	+0.286	+5.108	.002	.008	3	1
LIHC	LINC02186 →	+0.096	+5.758	<.001	.003	3	1
LUSC	RN7SKP228 →	+0.220	+5.548	.001	.004	3	1
LUSC	RNU6-1092P →	+0.671	+5.211	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

RNA5SP386 by LSM8 expression — LIHC

Explore this box plot interactively →