LSM8

Across TCGA pan-cancer cohorts, LSM8 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of LSM8’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where LSM8 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LSM8 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

HNSC, KIRC, and COAD are the cancer types where LSM8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LSM8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	+0.861	<.001	12	view →
KIRC	Male	IV	+0.616	<.001	11	view →
COAD	Male	All	+0.917	<.001	10	view →
BLCA	Female	III,IV	+0.742	<.001	10	view →
KIRP	All	IV	+1.215	<.001	9	view →
LIHC	Female	II,III,IV	+1.079	<.001	9	view →
LUAD	Male	II,III,IV	+0.778	<.001	9	view →
LUSC	Male	II,III,IV	+0.885	<.001	8	view →
UCEC	All	III,IV	+0.807	<.001	8	view →
STAD	Female	All	+0.965	<.001	7	view →
BRCA	All	II,III,IV	+0.335	<.001	6	view →
CHOL	Male	All	+2.118	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

LSM8–HNSC

Open the HNSC breakdown →