LSM8

Across TCGA pan-cancer cohorts, LSM8 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated LSM8 data layer compared with 1 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in kidney chromophobe (KICH), where higher LSM8 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated LSM8 expression acts as an unfavorable survival marker, although some lineages such as DLBC and BRCA show a favorable association.

KICH, ACC, and KIRC are the cancer types where LSM8 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	OS	Median	All	0.728	1.000	<.001	106	view →
ACC	DFS	Median	All	0.241	0.660	<.001	93	view →
KIRC	DFS	Tertile	IV	0.173	0.469	<.001	88	view →
UVM	DFS	Tertile	III,IV	0.194	0.760	.003	61	view →
LGG	OS	Median	All	0.739	0.880	<.001	45	view →
LIHC	OS	Median	All	0.706	0.842	<.001	39	view →
DLBC	DFS	Tertile	All	0.984	0.427	<.001	28	view →
BRCA	OS	Median	IV	0.945	0.513	.001	26	view →
KIRP	DFS	Quartile	All	0.525	0.878	.002	25	view →
THYM	OS	Tertile	All	1.000	0.607	<.001	21	view →
CESC	DFS	Median	IV	0.252	0.656	.020	18	view →
PRAD	DFS	Quartile	All	0.912	0.981	.002	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

LSM8–KICH (OS)

Open the KICH breakdown →