LRRN4

Across TCGA cell cohorts, LRRN4 mutation is significantly associated with the RNA expression of many other genes, with 284 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LRRN4-associated genes across cancer lineages are SENP3, CTDNEP1, and CD300H. Each is linked with LRRN4 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRRN4-to-partner and partner-to-LRRN4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SENP3 grouped by LRRN4-low versus LRRN4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRN4→partner) and Y-score (partner→LRRN4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SENP3 →	+0.473	+3.502	.006	.001	3	2
LARGE_INTESTINE	CTDNEP1 →	+0.573	+3.502	<.001	.001	3	2
LARGE_INTESTINE	CD300H →	+0.018	+2.830	<.001	.004	3	2
LUNG_SCLC	OR11L1 →	+0.055	+4.643	<.001	.004	3	1
LUNG_SCLC	CCT8L2 →	+0.017	+4.643	<.001	.004	3	1
LARGE_INTESTINE	CNIH1 →	+0.424	+2.451	.009	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 284 associations by consensus.

SENP3 by LRRN4 expression — LARGE_INTESTINE

Explore this box plot interactively →