LRRN4

Across TCGA pan-cancer cohorts, LRRN4 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of LRRN4’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where LRRN4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LRRN4 is over-expressed in tumor, although a few such as LUAD and KIRC show the opposite, repressed pattern.

HNSC, KIRP, and COAD are the cancer types where LRRN4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LRRN4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+0.686	<.001	12	view →
KIRP	All	II,III,IV	+2.753	<.001	11	view →
COAD	Female	All	+0.391	<.001	11	view →
LUAD	Male	II,III,IV	−2.313	<.001	9	view →
KIRC	All	III,IV	−1.397	<.001	9	view →
LUSC	Female	II,III,IV	−4.352	<.001	8	view →
KICH	Female	II,III,IV	−3.290	<.001	8	view →
BLCA	Male	III,IV	+0.612	.001	6	view →
STAD	Male	All	+0.650	.018	4	view →
CHOL	All	All	+1.841	<.001	3	view →
BRCA	All	III,IV	−0.242	.043	2	view →
THCA	All	All	+0.135	.013	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

LRRN4–HNSC

Open the HNSC breakdown →