LRRK2-DT

RNA expression — cross-omics
Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, LRRK2-DT RNA expression is significantly associated with the protein abundance of many other proteins, with 17,487 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible LRRK2-DT-associated proteins across cancer lineages are ARHGAP31_S1432, PIP4K2A, and TBC1D2B. Each is linked with LRRK2-DT in more than 6 cancer types. Because this analysis shows association rather than direction, both LRRK2-DT-to-partner and partner-to-LRRK2-DT results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRK2-DT→partner) and Y-score (partner→LRRK2-DT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LSCCARHGAP31_S1432 →+0.811+0.889<.001<.00136
OVPIP4K2A →+0.487+0.275<.001.00736
UCECTBC1D2B →+0.314+0.542<.001<.00136
HNSCWIPF1 →+0.386+0.360<.001.00636
OVANKRD44 →+0.654+0.461<.001.00227
OVDOCK8 →+0.442+0.451.003<.00136
Each partner links to its Q-omics profile. Showing the 6 strongest of 17,487 associations by consensus.

Exploration