LRRD1

Across TCGA patient cohorts, LRRD1 mutation is significantly associated with the RNA expression of many other genes, with 2,919 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRRD1-associated genes across cancer lineages are RN7SL578P, MIR5582, and ALDOA. Each is linked with LRRD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRRD1-to-partner and partner-to-LRRD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL578P grouped by LRRD1-low versus LRRD1-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRD1→partner) and Y-score (partner→LRRD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	RN7SL578P →	+0.172	+5.039	<.001	.008	3	2
CESC	MIR5582 →	+0.880	+3.783	<.001	.005	3	2
UCEC	ALDOA →	+0.437	+2.050	<.001	<.001	3	2
UCEC	SLC25A4 →	+0.443	+1.818	<.001	<.001	3	2
UCEC	BAG3 →	+0.561	+2.321	<.001	<.001	3	2
UCEC	COX11 →	+0.352	+1.399	.003	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,919 associations by consensus.

RN7SL578P by LRRD1 expression — READ

Explore this box plot interactively →