LRRD1

Across TCGA patient cohorts, LRRD1 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRRD1-associated genes across cancer lineages are VHL, ASNS, and ATM. Each is linked with LRRD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRRD1-to-partner and partner-to-LRRD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VHL grouped by LRRD1-low versus LRRD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRD1→partner) and Y-score (partner→LRRD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	VHL →	-0.680	-1.584	.002	.017	3	2
UCEC	ASNS →	+0.330	+1.765	.004	.013	3	2
UCEC	ATM →	-0.413	-2.209	.004	.009	3	2
UCEC	4E-BP1 →	+0.281	+3.807	.001	<.001	3	2
UCEC	14-3-3_beta →	-0.090	-1.780	.005	.024	3	1
UCEC	EGFR_pY1068 →	-0.198	-1.222	.015	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

VHL by LRRD1 expression — UCEC

Explore this box plot interactively →