LRRC75B

Across TCGA patient cohorts, LRRC75B mutation is significantly associated with the RNA expression of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRRC75B-associated genes across cancer lineages are SMIM11B, IGKV1D-12, and OR2W2P. Each is linked with LRRC75B in more than 1 cancer types. Because this analysis shows association rather than direction, both LRRC75B-to-partner and partner-to-LRRC75B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SMIM11B grouped by LRRC75B-low versus LRRC75B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC75B→partner) and Y-score (partner→LRRC75B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SMIM11B →	+0.033	+3.826	<.001	.001	3	1
UCEC	IGKV1D-12 →	+1.195	+3.595	.006	.006	3	1
COAD	OR2W2P →	+0.074	+5.122	<.001	.004	3	1
COAD	MTND5P27 →	+0.156	+5.917	<.001	.001	3	1
COAD	BPY2DP →	+0.230	+6.409	<.001	<.001	3	1
COAD	RN7SL98P →	+0.269	+6.278	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

SMIM11B by LRRC75B expression — UCEC

Explore this box plot interactively →