LRRC75B

Across TCGA pan-cancer cohorts, LRRC75B RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated LRRC75B data layer.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher LRRC75B RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated LRRC75B expression acts as an unfavorable survival marker, although some lineages such as LGG and THYM show a favorable association.

ACC, LGG, and THYM are the cancer types where LRRC75B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.408	0.738	<.001	95	view →
LGG	OS	Median	All	0.871	0.750	<.001	34	view →
THYM	DFS	Tertile	All	0.921	0.610	.005	24	view →
BLCA	DFS	Tertile	IV	0.327	0.671	.018	12	view →
GBM	DFS	Quartile	All	0.427	0.214	.034	9	view →
KIRP	OS	Median	II,III,IV	0.883	0.746	.024	9	view →
SKCM	OS	Tertile	All	0.829	0.904	.012	9	view →
LUAD	OS	Tertile	All	0.839	0.759	.019	7	view →
ESCA	OS	Median	III,IV	0.704	0.428	.002	6	view →
MESO	OS	Quartile	II,III,IV	0.317	0.575	.017	6	view →
PAAD	OS	Tertile	All	0.304	0.563	.018	6	view →
THCA	DFS	Tertile	All	0.965	0.900	.008	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

LRRC75B–ACC (DFS)

Open the ACC breakdown →