LRRC75A

Across TCGA patient cohorts, LRRC75A mutation is significantly associated with the total protein of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRRC75A-associated genes across cancer lineages are 14-3-3_beta, eIF4G, and FOXO3a_pS318_S321. Each is linked with LRRC75A in more than 1 cancer types. Because this analysis shows association rather than direction, both LRRC75A-to-partner and partner-to-LRRC75A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by LRRC75A-low versus LRRC75A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC75A→partner) and Y-score (partner→LRRC75A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.093	-2.295	.024	.033	3	1
UCEC	eIF4G →	+0.316	+1.807	.013	.027	3	1
UCEC	FOXO3a_pS318_S321 →	-0.130	-2.212	.011	.010	3	1
UCEC	GAPDH →	+0.618	+2.584	.005	.010	3	1
UCEC	GATA6 →	-0.171	-3.155	.007	.018	3	1
UCEC	INPP4B →	-0.269	-2.000	.044	.030	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

14-3-3_beta by LRRC75A expression — UCEC

Explore this box plot interactively →