LRRC75A

Across TCGA pan-cancer cohorts, LRRC75A RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated LRRC75A data layer compared with 1 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher LRRC75A RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated LRRC75A expression acts as an unfavorable survival marker, although some lineages such as SCLC and STAD show a favorable association.

UVM, SCLC, and STAD are the cancer types where LRRC75A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Tertile	All	0.283	0.800	<.001	113	view →
SCLC	OS	Tertile	All	0.673	0.290	<.001	80	view →
STAD	DFS	Quartile	All	0.733	0.471	<.001	67	view →
MESO	DFS	Quartile	III,IV	0.326	0.637	.006	57	view →
LGG	OS	Median	All	0.714	0.902	<.001	54	view →
KIRP	OS	Median	III,IV	0.496	0.803	.003	48	view →
UCEC	OS	Tertile	All	0.807	0.905	.001	44	view →
THCA	OS	Tertile	III,IV	1.000	0.750	.002	43	view →
PAAD	DFS	Quartile	All	0.413	0.125	<.001	36	view →
UCS	OS	Median	II,III,IV	0.607	0.242	.009	34	view →
ACC	DFS	Median	All	0.264	0.630	.001	32	view →
KIRC	DFS	Tertile	All	0.936	0.806	.003	32	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

LRRC75A–UVM (DFS)

Open the UVM breakdown →