LRRC75A

Across TCGA pan-cancer cohorts, LRRC75A RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of LRRC75A’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where LRRC75A RNA is repressed in tumor relative to normal tissue. In most cancer types LRRC75A is over-expressed in tumor, although a few such as COAD and LUAD show the opposite, repressed pattern.

COAD, THCA, and KIRC are the cancer types where LRRC75A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LRRC75A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	−1.423	<.001	9	view →
THCA	Female	II,III,IV	+1.317	<.001	8	view →
KIRC	All	All	+0.438	<.001	8	view →
LUAD	Female	II,III,IV	−0.750	<.001	6	view →
CHOL	All	All	+1.547	<.001	5	view →
STAD	All	II,III,IV	+1.039	.007	5	view →
LUSC	All	All	−0.735	<.001	5	view →
LIHC	All	All	+0.243	<.001	5	view →
READ	All	All	−1.162	.004	3	view →
UCEC	All	All	−0.439	.049	2	view →
KICH	Male	III,IV	−0.512	.030	1	view →
HNSC	All	All	+0.154	.043	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

LRRC75A–COAD

Open the COAD breakdown →