Across TCGA patient cohorts, LRRC74B mutation is significantly associated with the RNA expression of many other genes, with 791 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRRC74B-associated genes across cancer lineages are RNU6-1140P, SNRPGP17, and RN7SL840P. Each is linked with LRRC74B in more than 1 cancer types. Because this analysis shows association rather than direction, both LRRC74B-to-partner and partner-to-LRRC74B results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC74B→partner) and Y-score (partner→LRRC74B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-1140P →	+0.315	+2.370	.006	.008	3	2
UCEC	SNRPGP17 →	+0.247	+2.557	.008	.001	3	1
UCEC	RN7SL840P →	+0.413	+2.232	<.001	.007	3	1
UCEC	CWC25 →	+0.495	+3.617	.004	.001	3	1
UCEC	IGHV2-70 →	+1.967	+3.584	.001	.003	3	1
UCEC	SNORD116-4 →	+1.214	+2.590	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 791 associations by consensus.

Exploration

LRRC74B survival (RNA) · tumor vs normal (RNA) · all LRRC74B data types