Across TCGA pan-cancer cohorts, LRRC74B RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated LRRC74B data layer compared with 3 for mutation status.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher LRRC74B RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated LRRC74B expression acts as an unfavorable survival marker, although some lineages such as UCEC and HNSC show a favorable association.
KIRC, UCEC, and KICH are the cancer types where LRRC74B RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.