Across TCGA pan-cancer cohorts, LRRC74B RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of LRRC74B’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where LRRC74B RNA is repressed in tumor relative to normal tissue. In most cancer types LRRC74B is over-expressed in tumor, although a few such as LUAD and LUSC show the opposite, repressed pattern.

LUAD, LUSC, and KICH are the cancer types where LRRC74B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LRRC74B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	All	All	−0.440	<.001	7	view →
LUSC	All	II,III,IV	−0.663	<.001	6	view →
KICH	Female	All	−0.015	.015	2	view →
CHOL	All	All	+0.015	.046	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: LRRC74B RNA expression & survival · all LRRC74B data types