Across TCGA patient cohorts, LRRC74B mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRRC74B-associated genes across cancer lineages are A-Raf_pS299, INPP4B, and JNK_pT183_Y185. Each is linked with LRRC74B in more than 1 cancer types. Because this analysis shows association rather than direction, both LRRC74B-to-partner and partner-to-LRRC74B results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC74B→partner) and Y-score (partner→LRRC74B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.151	-3.000	.015	.036	3	1
UCEC	INPP4B →	-0.356	-3.000	.035	.036	3	1
UCEC	JNK_pT183_Y185 →	-0.266	-3.308	.002	.010	3	1
UCEC	MEK1 →	+0.456	+3.321	.017	.010	3	1
UCEC	ASNS →	+0.585	+3.321	.001	.010	3	1
UCEC	Caspase-8 →	-0.288	-2.973	.028	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

Exploration

LRRC74B survival (RNA) · tumor vs normal (RNA) · all LRRC74B data types