LRRC71

Across TCGA patient cohorts, LRRC71 mutation is significantly associated with the RNA expression of many other genes, with 1,918 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRRC71-associated genes across cancer lineages are RNU6-81P, RPL23AP89, and TUBGCP5. Each is linked with LRRC71 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRRC71-to-partner and partner-to-LRRC71 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-81P grouped by LRRC71-low versus LRRC71-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC71→partner) and Y-score (partner→LRRC71) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RNU6-81P →	+0.248	+9.057	<.001	.003	3	2
COAD	RPL23AP89 →	+0.316	+3.364	.001	.002	3	2
UCEC	TUBGCP5 →	+0.497	+3.470	<.001	.002	3	2
UCEC	UHRF1 →	+0.838	+2.513	<.001	.001	3	2
BLCA	MIR4734 →	+0.602	+4.268	<.001	.008	3	2
UCEC	COX15 →	+0.479	+3.467	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,918 associations by consensus.

RNU6-81P by LRRC71 expression — BRCA

Explore this box plot interactively →