LRRC57

Across TCGA patient cohorts, LRRC57 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible LRRC57-associated genes across cancer lineages are p27_pT198, STAT3_pY705, and ASNS. Each is linked with LRRC57 in more than 1 cancer types. Because this analysis shows association rather than direction, both LRRC57-to-partner and partner-to-LRRC57 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p27_pT198 grouped by LRRC57-low versus LRRC57-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LRRC57→partner) and Y-score (partner→LRRC57) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p27_pT198 →	+0.150	+3.169	.010	.020	3	1
UCEC	STAT3_pY705 →	-0.633	-3.169	<.001	.020	3	1
UCEC	ASNS →	+0.620	+3.169	.001	.020	3	1
UCEC	C-Raf →	+0.185	+3.169	.018	.020	3	1
UCEC	MEK1 →	+0.673	+3.169	<.001	.020	1	1
UCEC	Notch1 →	+0.202	+3.169	.009	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

p27_pT198 by LRRC57 expression — UCEC

Explore this box plot interactively →