LRRC57

Across TCGA pan-cancer cohorts, LRRC57 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated LRRC57 data layer compared with 7 for mutation status.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher LRRC57 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated LRRC57 expression acts as an unfavorable survival marker, although some lineages such as KIRC and GBM show a favorable association.

KIRC, ACC, and HNSC are the cancer types where LRRC57 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.733	0.510	.002	63	view →
ACC	DFS	Tertile	All	0.372	0.810	<.001	49	view →
HNSC	OS	Tertile	III,IV	0.292	0.614	.005	30	view →
CESC	DFS	Tertile	II,III,IV	0.702	0.927	.002	30	view →
BLCA	OS	Quartile	II,III,IV	0.364	0.581	.007	26	view →
LIHC	DFS	Tertile	All	0.347	0.492	.004	23	view →
PAAD	DFS	Median	All	0.204	0.387	.005	23	view →
GBM	DFS	Median	All	0.375	0.198	.014	20	view →
ESCA	OS	Median	IV	0.222	0.698	.006	18	view →
LGG	OS	Tertile	All	0.740	0.933	.001	16	view →
KIRP	DFS	Quartile	IV	0.043	1.000	.038	12	view →
SKCM	OS	Tertile	IV	0.681	0.180	.027	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

LRRC57–KIRC (DFS)

Open the KIRC breakdown →